Mulberry Leaf Extract
Mulberry trees belong to the Moraceae family and grow in hot and humid climates. The dried
leaves of Morus alba L. (white mulberry) are used to produce Mulberry leaf extract. Mulberry
leaves have an ovate to broadly ovate shape with a round or heart-shaped base, tapering top,
serrated edge and slender petiole. The surface of the leaves is glabrous and shiny, and the
length of the leaves is around 5 cm to 7.5 cm. (1)
Morus alba L. leaves have been widely used for thousands of years in Asian countries, mainly
for treating diabetes and hypertension. Additionally, they have been used to treat fever and
cough, infertility, snake bites, cancer, blindness and hyperpigmentation. The anti-diabetes
activity of Mulberry leaf extract is reported in many studies. In a study published in 2019,
anti-insulin resistance of Mulberry leaf extract is observed in diabetic rats. (2) It is stated in
another study that the Mulberry leaf extract can suppress raised blood glucose levels after
having a carbohydrate-rich meal by inhibiting the activity of disaccharidases in the small
intestine of rats. (3) According to Kim et al. Morus alba leaf extract has more impact on
diabetes than other medicinal plants such as Citrus unshiu, Dioscorea batatas and
Chrysanthemum coronarium. (4) Similarly, Kumar stated in his PhD thesis that Mulberry leaf
extract has a strong anti-diabetic property equal to the hypoglycemic effect of glibenclamide
and metformin. (5)
To conclude, many clinical studies have proven the antidiabetic, antioxidant, antibacterial,
anti-inflammatory, anticancer, cardiovascular, hypolipidemic, and antiatherogenic properties
of white mulberry leaves.
Mulberry leaves are rich in flavonoids and therefore capable of lowering blood sugar,
reducing blood lipids, resisting viruses, resisting ageing and enhancing immunity. (2) They
also contain nitrogen-involving sugars such as 1-Deoxynorijimycin (DNJ). DNJ works as a
potent α-glucosidase inhibitor, therefore responsible for the anti-diabetic property of the
Mulberry leaf extract. (3) Bionorm’s high-quality Mulberry leaf extract produced from Morus
Alba L. contains more than 0.5% DNJ and more than 15% total flavonoids.
1. Ruiyuan Zhang, Qian Zhang, Shun Zhu, Biyang Liu, Fang Liu, Yao Xu, Mulberry leaf
(Morus alba L.): A review of its potential influences in mechanisms of action on
metabolic diseases, Pharmacological Research, Volume 175, 2022, 106029, ISSN
1043-6618. doi: 10.1016/j.phrs.2021.106029.
2. Guangqun Ma, Xiaoyun Chai, Guige Hou, Fenglan Zhao, Qingguo Meng,
Phytochemistry, bioactivities and future prospects of mulberry leaves: A review, Food
Chemistry, Volume 372, 2022, 131335, ISSN 0308-8146.
3. Miyahara, M. Miyazawa, S. Satoh, A. Sakai, S. Mizusaki, Inhibitory effects of
mulberry leaf extract on postprandial hyperglicemia in normal rats. J. Nutr. Sci.
Vitaminol, Tokyo, 2004 doi: 10.3177/jnsv.50.161
4. S.H. Lee, S.Y. Choi, H. Kim, J.S. Hwang, B.G. Lee, J.J. Gao, S.Y. Kim Mulberroside
F isolated from the Leaves of Morus alba inhibits melanin biosynthesis Biol. Pharm.
Bull., 25 (2002), pp. 1045-1048
5. M.N. Kumar Evaluation of hypoglycemic activity of Morus alba in alloxaninduced
diabetic albino rats PhD Thesis, Rajir Gandhi University of Health
Sciences, BangaloreKarnataka (2012)