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Ruscogenins

Ruscus aculetaus L.

95-103% by HPLC

  • Chronic Venous Insufficiency
  • Antihaemorrhoidal
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Description

Ruscus aculeatus is a threatened medicinal plant whose main bioactive components, the ruscogenins, have long been used in the treatment of hemorrhoids and varicose veins. They are used for treating circulatory diseases of the lower limbs, hemorrhoids and some inflammatory conditions of anorectal mucosa. Traditional herbal medicinal product to relieve symptoms of discomfort and heaviness of legs related to minor venous circulatory disturbances. Traditional herbal medicinal product for symptomatic relief of itching and burning associated with haemorrhoids, after serious conditions have been excluded by a medical doctor.Several clinical observations reveal the vasculoprotective and phlebotonic properties of butcher’s broom-based preparations. Which makes it a very interesting active for undereye puffiness.Ruscogenin activates the microcirculation and protects cutaneous integrity with various mechanisms.

Ruscogenin reduces cell permeability through its anti-elastase activity. Elastase is an enzyme that degrades elastin, the main component of the elastic fibres. Collagen and elastin are the main components of the extracellular matrix. The anti-elastase activity of ruscogenin helps to prevent the degradation of the perivascular components and thus reduce cell permeability.

Ruscogenin also has vasoconstrictive properties via adrenergic mechanisms. Its effectiveness has been demonstrated in vivo. Certain studies show that it is an alpha-adrenergic blockade and, the vasoconstrictive effect may be mediated by calcium and the alpha-1 adrenergic receptors.

These vasoconstrictive and permeability reduction properties enable ruscogenin to activate the microcirculation.

By stimulating blood circulation in the capillaries, ruscogenin helps to decongest the undereye puffiness caused by slow circulation. These elements demonstrate the interest of using ruscogenin to treat undereye puffiness.