Anti-cancer

Oleandrin

Oleandrin is extracted from the roots of Nerium species, which are native to Mediterranean regions of Africa and Europe, oleandrin is the most prominent cardiac glycoside in nerium. Oleander is one of the most poisonous plants in the world and contains numerous toxic compounds. The toxicity of Oleander is considered extremely high and it has been reported that only a small amount had lethal or near lethal effects. The aqueous extract of N. oleander L. has been undergoing clinical investigations as an anticancer agent. Oleandrin and its aglycone oleandrigenin are the active compounds that are isolated from this plant which shown to have anticancer properties. Anvirzel has also revealed cytotoxicity in human tumor cell lines with evidence of apoptosis as a principal mode of cell death.